DNA methylation and DNA methyltransferases
نویسندگان
چکیده
منابع مشابه
DNA Methyltransferases and Methylation of CpG islands
DNA methylation is a critical mechanism of epigenetic modification involved in gene expression programming, that can promote the development of several cancers, including breast cancer. The methylation of CpG islands by DNA methyltransferases is reversible and has been shown to modify the transcriptional activity of key proliferation genes or transcription factors involved in suppression or pro...
متن کاملChimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
Gene silencing by targeted DNA methylation has potential applications in basic research and therapy. To establish targeted methylation in human cell lines, the catalytic domains (CDs) of mouse Dnmt3a and Dnmt3b DNA methyltransferases (MTases) were fused to different DNA binding domains (DBD) of GAL4 and an engineered Cys2His2 zinc finger domain. We demonstrated that (i) Dense DNA methylation ca...
متن کاملAdoMet-dependent methylation, DNA methyltransferases and base flipping.
Twenty AdoMet-dependent methyltransferases (MTases) have been characterized structurally by X-ray crystallography and NMR. These include seven DNA MTases, five RNA MTases, four protein MTases and four small molecule MTases acting on the carbon, oxygen or nitrogen atoms of their substrates. The MTases share a common core structure of a mixed seven-stranded beta-sheet (6 downward arrow 7 upward a...
متن کاملRole of DNA methylation and the DNA methyltransferases in learning and memory
Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in learning and memory. Methylation of cytosine nucleotides has historically been considered the strongest and least modifiable of epigenetic marks. Accumulating recent data suggest that rapid and dynamic methylation and demethylation of specific genes in the brain may play a fundamental role in learning, m...
متن کاملIn Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood. Here, we describe a comprehensive analysis of DNA methylation patterns generated by high resolution sequencing of hairpin-bisulfite amplicons of selected single copy genes and repetitive elements (LINE1, B1, IAP-LTR-retrotransposons,...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2017
ISSN: 1756-8935
DOI: 10.1186/s13072-017-0130-8